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Tirzepatide is administered as a once-weekly subcutaneous injection , typically starting at a low dose (2.5 mg) and gradually titrated upwards (to 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg) at approximately 4-week intervals to optimise efficacy whilst minimising gastrointestinal side effects

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This is an emerging area of research

J Transl Med 22 , 114 (2024)

Since natural glutathione production also decreases, there's little defense against the increase in oxidative stress